Hans Chiari

Hans Chiari (1851-1916) was an Austrian pathologist. He is named after and affiliated with the Chiari malformations; Type II Chiari malformation (Arnold–Chiari malformation) and Budd–Chiari syndrome (1899).

Biography
Born November 4, 1851 in Vienna, Austria
Studied medicine in Vienna and worked as an assistant at the Vienna Institute of Pathology under Karl Rokitansky (1804–1878)
1875 – Graduated medical school from the Unviersity of Vienna
1878 – Habilitated in pathological anatomy in Vienna
1882 – Professor extraordinarius of pathology at the German University in Prague
1883 – Appointed professor ordinarius and superintendent of the pathological-anatomical museum in Prague
1906 – Commenced as professor ordinarius at the University of Strasbourg
Died May 6, 1916 in Strasbourg following a throat infection

Hans Chiari published a case series of three patients with hepatic vein thrombosis, and a literature review of seven additional patients. He named the disease ‘phlebitis obliterans‘, and postulated that the thrombosis was a complication of endo-phlebitis likely from syphilis. Lange postulated an inflammatory process in hepatic vein thrombosis prior, in 1886.

Chiari published across a wide range of pathology, including malformations of the brainstem and cerebellum, hepatic vein thrombosis, aortooesophageal fistula, choriocarcinoma, carotid artery plaques and thrombosis, autodigestion of the pancreas, and connections between the eustachian and thebesian heart valves.

Pathology of showed congested and necrotic livers, porto-mesenteric circulation congestion, large volume ascites, and minimal adventitial reaction without perivascular involvement on histology. Chiari provided the first clinical and pathological correlations of this syndrome.

Chiari malformations – abnormalities of the brain stem and cerebellum identified by Chiari on post-mortems. Type 1 (1891) – peg-like elongation of the cerebellar tonsils into the spinal canal through the foramen magnum; Type 2 aka Arnold Chiari malformation and Type 3 and 4.

Chiari network – mobile net-like connections between the valve of the coronary sinus and the valve of the inferior vena cava. An anatomical variant, usually of no clinical significance.

https://litfl.com/hans-chiari/

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